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Symbol Name ID |
Huwe1
HECT, UBA and WWE domain containing 1 MGI:1926884 |
| * | Aspects of the system are reported to show a normal phenotype. |
| Darker colors indicate more annotations |
| Human Phenotypes | Hypospadias |
Micropenis |
Cryptorchidism |
| Disease(s) Associated with HUWE1 | |||
| syndromic X-linked intellectual disability Turner type |
| Mouse Phenotypes | reproductive system phenotype |
oligozoospermia |
abnormal spermatocyte morphology |
abnormal spermatogonia morphology |
decreased male germ cell number |
increased male germ cell apoptosis |
increased testis apoptosis |
abnormal male germ cell physiology |
decreased testis weight |
small testis |
abnormal male meiosis |
arrest of spermatogenesis |
abnormal caput epididymis morphology |
male infertility |
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| Availability | Mouse Genotype | ||||||||||||||
| Huwe1tm1Alas/Y Tg(Stra8-icre)1Reb/0 (conditional) |
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| Huwe1tm1Alas/Y Tg(Spo11-cre)1Rsw/0 (conditional) |
* | ||||||||||||||
| Huwe1tm1Alas/Y Tg(Prm-cre)58Og/0 (conditional) |
* | ||||||||||||||
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO) |
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last database update 04/23/2024 MGI 6.23 |
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